Improving the diagnostic accuracy in parkinsonism: a three-pronged approach
Identifieur interne : 001299 ( Main/Corpus ); précédent : 001298; suivant : 001300Improving the diagnostic accuracy in parkinsonism: a three-pronged approach
Auteurs : Marjolein B. Aerts ; Rianne A J. Esselink ; Bart Post ; Bart P C. Van De Warrenburg ; Bastiaan R. BloemSource :
- Practical Neurology [ 1474-7758 ] ; 2012-04.
Abstract
Separating Parkinson's disease from the various causes of atypical parkinsonism (AP) is a common and clinically relevant challenge in clinical practice. Distinguishing between the different causes of AP is even more difficult. Here the authors discuss a systematic, clinically based and three-pronged approach that can assist clinicians in establishing the correct diagnosis in the consulting room. The three consecutive steps include: (1) to verify that the clinical syndrome truly represents parkinsonism (hypokinetic–rigid syndrome); (2) to search systematically for ‘red flags’ (alarm signs that may signal the presence of AP); and (3) to integrate these two steps, as a basis for a narrow differential diagnosis and a guide for further ancillary tests.
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DOI: 10.1136/practneurol-2011-000132
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Esselink</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Post, Bart" sort="Post, Bart" uniqKey="Post B" first="Bart" last="Post">Bart Post</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P C" last="Van De Warrenburg">Bart P C. Van De Warrenburg</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Bloem, Bastiaan R" sort="Bloem, Bastiaan R" uniqKey="Bloem B" first="Bastiaan R" last="Bloem">Bastiaan R. 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Aerts</name><affiliation><mods:affiliation>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Esselink, Rianne A J" sort="Esselink, Rianne A J" uniqKey="Esselink R" first="Rianne A J" last="Esselink">Rianne A J. 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Distinguishing between the different causes of AP is even more difficult. Here the authors discuss a systematic, clinically based and three-pronged approach that can assist clinicians in establishing the correct diagnosis in the consulting room. The three consecutive steps include: (1) to verify that the clinical syndrome truly represents parkinsonism (hypokinetic–rigid syndrome); (2) to search systematically for ‘red flags’ (alarm signs that may signal the presence of AP); and (3) to integrate these two steps, as a basis for a narrow differential diagnosis and a guide for further ancillary tests.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Marjolein B Aerts</name><affiliations><json:string>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>Rianne A J Esselink</name><affiliations><json:string>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>Bart Post</name><affiliations><json:string>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>Bart P C van de Warrenburg</name><affiliations><json:string>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item><json:item><name>Bastiaan R Bloem</name><affiliations><json:string>Department of Neurology, Parkinson Center Nijmegen (ParC), and Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Reviews</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Separating Parkinson's disease from the various causes of atypical parkinsonism (AP) is a common and clinically relevant challenge in clinical practice. 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